Since it launched for the 2008 model year, the Enclave has officially become the best-selling Buick vehicle of all time. It is currently split into three generations:
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First Generation (2008–2017)
- 3.6L V6 with a 6-speed automatic
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Second Generation (2018–2024)
- 3.6L V6 with a 9-speed automatic
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Third Generation (2025–Present)
- 2.5L 4-cyl with an 8-speed automatic